Inconclusive Findings: Now You See Them, Now You Don’t!

The environmental health literature is rife with controversial papers that evoke criticism, support, and, most importantly, a desire to better understand the findings put forth by the authors. A research article by Séralini and colleagues (Séralini et al. 2012), published in the journal Food and Chemical Toxicology (FCT), is one such article resulting in considerable discourse (Arjó et al. and a call for new research (European Commission 2013). This is all part of the scientific process in a modern research environment. However, the retraction of the article by Séralini et al. from FCT sets a new precedent in the management of peer-reviewed publications that we believe has serious implications for environ mental public health. The retraction announcement by the Editor-in-Chief specifically states, " Ultimately, the results presented (while not incorrect) are inconclusive, and therefore do not reach the threshold of publication for Food and Chemical Toxicology " (FCT 2013). The Editor-in-Chief also was very clear that he " found no evidence of fraud or intentional misrepresentation of the data. " This article (Séralini et al. 2012) has been controversial from its initial publication. We do not wish to discuss the merits of the authors' conclusions or their implications for the commercial products in question. Those issues have been debated in the open scientific literature since the publication of the paper, and we agree with many of the critiques. However, the retraction of any paper because it is " inconclusive " has adverse implications on the integrity of the concept of the peer-review process as the critical foundation of unbiased scientific inquiry. The paper was peer reviewed by scientists on behalf of the FCT and published accordingly. Hence, it initially met the threshold for publication. In our opinion, there must be a different threshold for forced retraction of the paper, and we believe that this paper did not reach that threshold. The COPE guidelines for retracting articles (Committee on Publication Ethics 2009) provide four reasons for retraction: scientific misconduct/honest error, prior publication, plagiarism, or unethical research. None of these reasons apply to this particular article, and yet Elsevier, a member of COPE, chose to retract the paper. The nature of science is such that individual studies are rarely, if ever, conclusive. Numerous published studies have later been found to be deeply flawed through further scientific investigation, as may well be the study by Séralini et al. To our knowledge, there is …